The quick answer
Both semaglutide labels list three areas: the abdomen, the thigh, and the upper arm. Don’t use the same spot every time, and the Wegovy pen and syringe instructions add: keep 2 inches (5 cm) from the belly button. The buttocks are not a listed site.
What each label says
| Medication | Sites | Upper arm | Rotation |
|---|---|---|---|
| Ozempic® Label | Abdomen, thigh, or upper arm | Listed in the Prescribing Information. Prefilled syringe instructions: back of upper arm “only with help from someone else.” | Use a different site when injecting in the same body region. The Medication Guide: “Do not use the same site for each injection.” |
| Wegovy® Label | Abdomen, thigh, or upper arm | Pen, HD pen, and FlexTouch: listed, no helper mentioned. Prefilled syringe: “only with help from someone else.” | “Rotate injection sites with each dose.” Same body area is fine, not the same spot. |
Pens and prefilled syringes
- Wegovy pen and HD pen. “You may inject into your upper leg (front of the thighs), lower stomach (keep 2 inches away from your belly button) or upper arm.”
- Wegovy FlexTouch. Keep a distance of 2 inches (5 cm) from your belly button.
- Ozempic and Wegovy prefilled syringes. Stomach area at least 2 inches from the belly button, thighs, or the back of the upper arm “only with help from someone else.” Avoid using the exact same spot as last time.
Skin to skip
The Wegovy pen instructions are the most specific: don’t inject where the skin is tender, bruised, red, or hard, and avoid scars or stretch marks. MedlinePlus gives the same advice for subcutaneous injections generally.
Rotating within an area
The Medication Guides for both products say to change (rotate) your injection site with each injection and not to use the same site for each injection. The Wegovy pen instructions say you may inject in the same body area, as long as it isn’t the same spot each time. Why rotation matters.
If you also use insulin
The Ozempic label says it is acceptable to inject Ozempic and insulin in the same body region, but not right next to each other. The Wegovy label doesn’t address this, so ask your prescriber.
Keeping a record
Print the free rotation chart (PDF) and tape it near your pens, or let StackLogR save the site in the same tap as the log and show which spot has rested longest. It’s a free GLP-1 tracker that keeps everything on your phone.
Using tirzepatide instead? See tirzepatide injection sites (Mounjaro, Zepbound).
FAQ
Where do you inject semaglutide?
The Ozempic and Wegovy labels both list the abdomen, the thigh, and the upper arm.
Can I inject Ozempic or Wegovy in my arm myself?
It depends on the device. The Wegovy pen, HD pen, and FlexTouch instructions list the upper arm with no helper. The Ozempic and Wegovy prefilled syringe instructions say the back of the upper arm only with help from someone else. Follow the instructions for the device you have.
How far from the belly button should a semaglutide injection be?
The Wegovy pen instructions and the prefilled syringe instructions say to keep 2 inches (5 cm) away from the belly button.
Can I use the same spot every time?
No. The Medication Guides say to change (rotate) your injection site with each injection and not to use the same site for each injection. The same body area is fine, just not the same spot.
Can I inject Ozempic and insulin in the same area?
The Ozempic label says it is acceptable to inject Ozempic and insulin in the same body region, but the injections should not be adjacent to each other.
What skin should I avoid?
The Wegovy pen instructions say not to inject where the skin is tender, bruised, red, or hard, and to avoid scars and stretch marks.